To a ch 3 cn-h 2 o solution (4 ml-2 ml) of 2-bromo-3'-methylpropiophenone 7c (400 mg, 176 mmol) was added pyrrolidine (150 μl, 176 mmol), and the mixture was allowed to react for 4 h at room temperature. It employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field also used as intermediate for 4-methylmethcathinone solubility. For 4-methylmethcathinone, the 4-methylbenzoyl cation at m/z 119 is formed, which subsequently loses co to form the methylphenyl cation with m/z 91 the loss of acetylene from the methylphenyl cation produces the m / z 65 ion.
Nation step involved reacting 4-methylpropiophenone with excess bromine (to form 2-bromo-4-methylpropiophenone) in the presence of glacial acetic acid at 25 c for 1 hour. 2-bromo-4'-methylpropiophenone to 1-(4-methylphenyl)-2methylaminopropanone hydrochloride 3 135g methylamine hcl in 15ml water 7 then was poured into 150ml ice-cold water forming a homogenous solution. 4-mmc hcl was synthesised in two stages following a modified method given by camilleri et al 20 the first α-bromination step involved reacting 4-methylpropiophenone with excess bromine (to form 2-bromo-4-methylpropiophenone) in the presence of glacial acetic acid at 25 °c for 1 hour.
A solution of α-bromo-4-methylpropiophenone (568 g, 25 mmol) and ethanolic methylamine (625 ml, 8 m, 50 mmol) in absolute ethanol (50 ml) was stirred overnight at room temperature. The bromination of the 4′-methylpropiophenone was achieved relationship between precursor material and the product using bromine in dichloromethane under mildly acidic catalysis derived from it can be expressed using rayleigh equations24 and gave the corresponding (±)-4′-methyl-2-bromopropiophe- the numerical expression of this. This route involved the bromination of 4-methylpropiophenone, which yielded 4-methyl-2-bromopropiophenone that was then reacted with methylamine hydrochloride and triethylamine to give 4-methylmethcathinone as a racemic mixture. Applications it employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field also used as intermediate for 4-methylmethcathinone.
Mephedrone, also known as 4-methyl methcathinone (4-mmc) or 4-methyl ephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes slang names include drone, m-cat, white magic and meow meow. Followed by reaction of the resulting 4-methylbromopropiophenone (1-(4-methylphenyl)-2- bromo-1-propanone) with an excess of methylamine or methylamine hydrochloride and an acid scavenger. It employed as an important intermediate for raw material, organic synthesis, agrochemical, pharmaceutical and dyestuff field also used as intermediate for 4-methylmethcathinone store at 4°c, store in cool, dry place in tightly closed container, away from oxidizing agent.
Benzoyl bromide 4'-bromopropiophenone 2-bromo-2-methylpropiophenone 4'-bromovalerophenone 4-bromobenzophenone 2-bromo-2-phenylacetophenone benzaldehyde p-hydroxybenzaldehyde 4-fluorobenzaldehyde 4-chlorobenzaldehyde benzoicacid 3-(4-isopropylphenyl)isobutyraldehyde aquantraal 2-chlorobenzaldehyde 4-dimethylaminobenzaldehyde 1-nonanal. The reaction mixture was allowed to stir, at room temperature and protected from light, until reaction completion and then concentrated under vacuum to give a light brown oil except 2-bromo-4′-methylpropiophenone which was a solid and was recovered from the reaction mixture by filtration. During the analysis of seized samples, suspected of containing 4-methylmethcathinone (mephedrone) and n-ethylcathinone (ethcathinone) additional compounds were observed in the gcms chromatogram. In the case of methylone, for example, 2-bromo-3,4-methylenedioxy-propiophenone can be prepared by reacting 3,4-methylenedioxypropiophenone with bromine these precursor substances are readily available and none of them is under international control.
Â 4-methyl methcathinone â hi bees, i've been bored over the last couple of days and had a few fun reagents lying around, so i though i'd tryand make some 1-(4-methylphenyl)-2-methylaminopropanone hydrochloride, or 4-methylmethcathinone as i suppose it would be commonly called. 4-methylmethcathinone 10 g of the 40-methyl-2-bromopropiophenone (44 mmol)was dissolved in 30 ml of ch2cl2 and added dropwise over an hour to a stirred solution of 03 g ofmethylamine hydrochloride (44 mmol) and 10 g of triethylamine (9 mmol) in 50 ml of ch2cl2. 248 ey santali et al / journal of pharmaceutical and biomedical analysis 56 (2011) 246-255 (2 ml), treated with hydrobromic acid (33% solution in acetic acid, 5ml) and stirred at room temperature for 1h. We started our activity in 2009 through this years we were consistently building leader position including new products in our offer in 2011 we launched our first e-store, and we are still gaining new experience and extending fields of our activity.