As most of the conventional drug delivery systems for treating colon disorders such as inflammatory bowel diseases, infectious diseases and colon cancer are failing as the drugs don't reach the site of action in appropriate concentration thus an effective and safe therapy of these colonic disorders using site specific drug delivery system the. 11 colon specific drug delivery system (csdds) the major goal of any drug delivery system is to supply a therapeutic amount of drug to a target site in a body, so that the desired drug. Colon-specific drug delivery has gained increasing attention in the treatment of colorectal cancer and other colon-related disorders, that is, crohn's disease (cd), ulcerative colitis (uc), irritable bowel syndrome and spastic colon chourasia mk, jain sk. Examples of mip-based drug delivery systems involve: (i) rate-programmed drug delivery, where drug diffusion from the system has to follow a specific rate profile, (ii) activation-modulated drug delivery, where the release is activated by some physical, chemical or biochemical processes and (iii) feedback-regulated drug delivery, where the rate.
The necessity and advantages of colon-specific drug delivery systems have been well recognized and documented in the past, the primary approaches to obtain colon-specific delivery achieved limited success and included prodrugs, ph- and time-dependent systems, and microflora-activated systems. Colon-specific drug delivery through the oral route has gained increased importance to treat local diseases in colon and to give potential delivery of drugs that are used. C o m page 863 introduction: colon specific drug delivery has gained increasing importance for the delivery of drugs in the treatment associated with the colon and also acts as the potential site.
A successful colon specific drug delivery system is one of that remains intact in the physiological environment of stomach and small intestine, but releases the drug in the colon in-vitro evaluation : different in vitro methods are used to evaluate the colonic drug delivery systems. In the recent year colonic drug delivery has gained importance for delivery of drug for the treatment of local diseases associated with colon and systemic delivery of therapeutic peptides and proteins. Colon specific drug delivery has gained increased importance not just for delivery of the drugs in the treatment associated with the colon, but also as a potential site for the systemic delivery of therapeutic peptides and proteins.
Colon-specific drug delivery systems (cdds) are desirable for the treatment of a range of local diseases such as ulcerative colitis, crohn's disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer. The powerpoint ppt presentation: colon targeted drug delivery is the property of its rightful owner do you have powerpoint slides to share if so, share your ppt presentation slides online with powershowcom. Colon specific drug delivery system hussain mobarak 1 , das biswajit 1 , chakraborty jashabir 2 1 pharmaceutics, girijananda chowdhury institute of pharmaceutical science, azara, hathkhoyapara, guwahati. Chitosan dispersed drug delivery system which was composed of active ingredient reservoir and the outer drug release regulating layer dispersing chitosan powder in hydrophobic polymer, was newly developed for colon-specific drug delivery (192.
Colon specific drug delivery is a reasonably recent approach to the treatment of diseases and irritable bowel syndrome, recommended treatments include the. Colon specific systems is most important delivery of those drug which are normally inactivated in the upper parts of the gastrointestinal tract (git) primary approaches for ctdds (colon targeted drug delivery system), which includes.
The colon is a site where both local and systemic delivery of drugs can takes place colon specific drug delivery has achieved importance for the delivery of drugs for the treatment of local diseases associated with the colon like crohn's disease, ulcerative colitis etc as well as for the. Introduction to the colon rationale of colon drug delivery system limitation and challenges introduction to colonic drug delivery system factors affecting colonic drug delivery pharmaceutical approaches for colon targeting list of contents: 2 12 july 2012.
Prodrugs and drug-delivery systems controlled by time, ph, and osmosis, are being used to prevent drug degradation in the stomach and small intestine and ensure drug release in the colon. • colon-specific drug delivery system is considered to be beneficial in the treatment of colon diseases • the colon is a site where both local and systemic. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, crohn's disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs1, 2 the colon specific drug delivery system (cdds) should be capable of.